Abstract Anaplastic thyroid cancer (ATC) is an infrequent thyroid tumor that usually occurs in elderly patients. There is often a history of previous differentiated thyroid cancer suggesting a biological progression. It is clinically characterized by a locally invasive cervical mass of rapid onset. Metastases are found at diagnosis in 50% of patients. Due to its […]
Abstract Medullary thyroid carcinoma (MTC) is an infrequent thyroid malignancy that is often diagnosed at advanced stage with consequent poor prognosis. Thus, the earlier the diagnosis of MTC, the better the prognosis. Unfortunately, the preoperative detection of MTC remains challenging in clinical practice. In fact, while ultrasound and fine-needle aspiration cytology have suboptimal performance in […]
Abstract We previously described the role of low-density lipoprotein (LDL) in aggressiveness in papillary thyroid cancer (PTC). Moreover, the MAPK signaling pathway in the presence of BRAF V600E mutation is associated with more aggressive PTC. Although the link between MAPK cascade and LDL receptor (LDLR) expression has been previously described, it is unknown whether LDL […]
Fabian Pitoia, Rafael Selbach Scheffel, Ines Califano, Alicia Gauna, Hernán Tala, Fernanda Vaisman, Alejandro Roman Gonzalez, Ana Oliveira Hoff & Ana Luiza Maia Abstract Radioiodine (RAI) refractory differentiated thyroid cancer is an uncommon and challenging situation that requires a multidisciplinary approach to therapeutic strategies. The definition of RAI-refractoriness is usually a clear situation in specialized centers. However, the right moment for initiation of multikinase […]
Robert Haddad, MD1; Rossella Elisei, MD2; Ana O. Hoff, MD3; Zhiyan Liu, MD, PhD4; Fabian Pitoia, MD, PhD5; Giancarlo Pruneri, MD6,7; Peter M. Sadow, MD, PhD8; Fernando Soares, MD, PhD9; Andrew Turk, MD10; Michelle D. Williams, MD11; Lori J. Wirth, MD12; Maria E. Cabanillas, MD13 Abstract Importance Thyroid epithelial malignant neoplasms include differentiated thyroid carcinomas (papillary, follicular, and oncocytic), follicular-derived high-grade thyroid carcinomas, and anaplastic and medullary thyroid carcinomas, with additional rarer subtypes. The discovery of neurotrophic tyrosine receptor kinase (NTRK) gene fusions has fostered developments in precision oncology, with […]
Abstract Background In patients with low-risk differentiated thyroid cancer (DTC), remnant ablation with radioiodine (RA) after total thyroidectomy (TT) is controversial. No benefits have been demonstrated in terms of mortality or disease-free survival. Recent evidence found that RA did not improve mid-term outcomes. Purpose To evaluate initial response to treatment and long-term follow-up status in […]
